|
KMID : 1140120070120010051
|
|
Cancer Prevention Research
2007 Volume.12 No. 1 p.51 ~ p.57
|
|
|
Effect of Leucocyanidins (Vitis vinifera L.) on Blood Glucose and Biochemical Data in Streptozotocin-treated Newborn Rats
|
|
Kim Shin-Hee
Lee Jung-Sik
Park Song-Hee
Seo Hee-Kyung
Lim Su-Jin
Jhee Ok-Hwa
Park Yoo-Sin
Park Jin-Hee
Kang Ju-Seop
|
|
|
Abstract
|
|
|
To investigate the effect of leucocyanidins (LCN) in streptozotocin (STZ)-treated newborn diabetic rats, we evaluated the changes of body weight, fasting blood glucose level, oral glucose tolerance test (OGTT), insulin level and biochemical parameters after the administration of LCN in STZ-treated newborn rats. In 7 days of age rats were received single intraperitoneal injection of 60 mg/kg of STZ. Animals were divided into four groups; STZ-induced DM group; LCN (LL)-treated group (30 mg/kg, i.p), LCN (HL)-treated group (60 mg/kg, i.p) at 8 weeks after the single injection of STZ (60 mg/kg, i.p.), respectively during 4 weeks.; Normal control (NC) group received vehicle and saline. Mean body weight
change of DM group was retarded greatly by STZ-exposure. While, body weights of LL and HL groups were increased. Fasting blood glucose levels of LL and HL groups were reduced about 19% or 27% by LCN injection. The insulin level did not differ after treatment with LCN in experimental rats. The results of OGTT was improved in HL group compared to DM group. In LL and HL groups, blood glucose, ALT and AST and BUN levels were attenuated compared to DM group. From the results, it was suggested that LCN had a tendency to decrease on STZ-induced toxicity in terms of monitoring the blood glucose in fasting, OGTT and some biochemical parameter of the rat. (Cancer Prev Res 12, 51-57, 2007)
|
|
|
KEYWORD
|
|
|
Streptozotocin, Leucocyanidins, Blood glucose, OGTT, Diabetes
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|